pentobarbital will lower the extent or result of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Result of coadministering a powerful CYP3A4 inducer with fedratinib hasn't been examined.pentobarbital will lower the level or effect of ripretinib by influencing hepatic/intestinal enzyme CYP3A4 metab